Mouse Model for Human Arginase Deficiency

Deficiency of liver arginase (AI) causes hyperargininemia (OMIM 207800), a disorder characterized by progressive mental impairment, growth retardation, and spasticity and punctuated by sometimes fatal episodes of hyperammonemia. We constructed a knockout mouse strain carrying a nonfunctional AI gene...

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Autors principals: Iyer, Ramaswamy K., Yoo, Paul K., Kern, Rita M., Rozengurt, Nora, Tsoa, Rosemarie, O'Brien, William E., Yu, Hong, Grody, Wayne W., Cederbaum, Stephen D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
Matèries:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC133904/
https://ncbi.nlm.nih.gov/pubmed/12052859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.13.4491-4498.2002
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