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Regulation of c-myc mRNA Decay by Translational Pausing in a Coding Region Instability Determinant

A 249-nucleotide coding region instability determinant (CRD) destabilizes c-myc mRNA. Previous experiments identified a CRD-binding protein (CRD-BP) that appears to protect the CRD from endonuclease cleavage. However, it was unclear why a CRD-BP is required to protect a well-translated mRNA whose co...

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Udgivet i:Mol Cell Biol
Principais autores: Lemm, Ira, Ross, Jeff
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2002
Fag:
Gene Expression
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133878/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12024010/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.12.3959-3969.2002
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