The PERK Eukaryotic Initiation Factor 2α Kinase Is Required for the Development of the Skeletal System, Postnatal Growth, and the Function and Viability of the Pancreas

Phosphorylation of eukaryotic initiation factor 2α (eIF-2α) is typically associated with stress responses and causes a reduction in protein synthesis. However, we found high phosphorylated eIF-2α (eIF-2α[P]) levels in nonstressed pancreata of mice. Administration of glucose stimulated a rapid dephos...

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Detalhes bibliográficos
Main Authors: Zhang, Peichuan, McGrath, Barbara, Li, Sheng'ai, Frank, Ami, Zambito, Frank, Reinert, Jamie, Gannon, Maureen, Ma, Kun, McNaughton, Kelly, Cavener, Douglas R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133833/
https://ncbi.nlm.nih.gov/pubmed/11997520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.11.3864-3874.2002
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