Essential Role of AKT-1/Protein Kinase Bα in PTEN-Controlled Tumorigenesis

PTEN is mutated at high frequency in many primary human cancers and several familial cancer predisposition disorders. Activation of AKT is a common event in tumors in which the PTEN gene has been inactivated. We previously showed that deletion of the murine Pten gene in embryonic stem (ES) cells led...

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Main Authors: Stiles, Bangyan, Gilman, Valeriya, Khanzenzon, Natalya, Lesche, Ralf, Li, Annie, Qiao, Rong, Liu, Xin, Wu, Hong
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC133830/
https://ncbi.nlm.nih.gov/pubmed/11997518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.11.3842-3851.2002
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