Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity

It is widely accepted that reactive oxygen species (ROS) promote tumorigenesis. However, the exact mechanisms are still unclear. As mice lacking the peroxidase peroxiredoxin1 (Prdx1) produce more cellular ROS and die prematurely of cancer, they offer an ideal model system to study ROS-induced tumori...

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Autori principali: Cao, Juxiang, Schulte, Jennifer, Knight, Alexander, Leslie, Nicholas R, Zagozdzon, Agnieszka, Bronson, Roderick, Manevich, Yefim, Beeson, Craig, Neumann, Carola A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688529/
https://ncbi.nlm.nih.gov/pubmed/19369943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.101
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