Integrin-Linked Kinase Regulates PTEN Activity to Promote Tumorigenesis in Neuroblastoma Cells

BACKGROUND: The phosphatidylinositol 3-kinase (PI3K), a critical intracellular pathway, is negatively regulated by phosphatase and tensin homologue (PTEN). Integrin-linked kinase (ILK) induces phosphorylation of Akt leading to an increase in cell survival. However, a potential interaction between IL...

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Main Authors: Taylor, Chase J., Qiao, Jingbo, Colon, Nadja C., Schlegel, Cameron, Josifi, Erlena, Chung, Dai H.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668783/
https://ncbi.nlm.nih.gov/pubmed/21719054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2011.05.007
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