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RAG-Mediated V(D)J Recombination Is Not Essential for Tumorigenesis in Atm-Deficient Mice

Atm-deficient mice die of malignant thymic lymphomas characterized by translocations within the Tcrα/δ locus, suggesting that tumorigenesis is secondary to aberrant responses to double-stranded DNA (dsDNA) breaks that occur during RAG-dependent V(D)J recombination. We recently demonstrated that deve...

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Udgivet i:Mol Cell Biol
Principais autores: Petiniot, Lisa K., Weaver, Zoë, Vacchio, Melanie, Shen, Rhuna, Wangsa, Danny, Barlow, Carrolee, Eckhaus, Michael, Steinberg, Seth M., Wynshaw-Boris, Anthony, Ried, Thomas, Hodes, Richard J.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2002
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133758/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11940674/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.9.3174-3177.2002
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