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p53 Is Necessary for the Apoptotic Response Mediated by a Transient Increase of Ras Activity

The tumor suppressor p53 eliminates cancer-prone cells via multiple mechanisms, including apoptosis. Ras elicits apoptosis in cells after protein kinase C (PKC) downregulation. However, the role of p53 in Ras-mediated apoptosis has not been fully investigated. Here, we demonstrate that mouse fibrobl...

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Bibliografiske detaljer
Main Authors: Ma, Peihong, Magut, Maureen, Chen, XinBin, Chen, Chang-Yan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2002
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC133752/
https://ncbi.nlm.nih.gov/pubmed/11940651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.9.2928-2938.2002
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