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The Two ADF-H Domains of Twinfilin Play Functionally Distinct Roles in Interactions with Actin Monomers

Twinfilin is a ubiquitous and abundant actin monomer–binding protein that is composed of two ADF-H domains. To elucidate the role of twinfilin in actin dynamics, we examined the interactions of mouse twinfilin and its isolated ADF-H domains with G-actin. Wild-type twinfilin binds ADP-G-actin with hi...

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Udgivet i:Mol Biol Cell
Principais autores: Ojala, Pauli J., Paavilainen, Ville O., Vartiainen, Maria K., Tuma, Roman, Weeds, Alan G., Lappalainen, Pekka
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Cell Biology 2002
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133594/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12429826/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.E02-03-0157
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