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The Two ADF-H Domains of Twinfilin Play Functionally Distinct Roles in Interactions with Actin Monomers

Twinfilin is a ubiquitous and abundant actin monomer–binding protein that is composed of two ADF-H domains. To elucidate the role of twinfilin in actin dynamics, we examined the interactions of mouse twinfilin and its isolated ADF-H domains with G-actin. Wild-type twinfilin binds ADP-G-actin with hi...

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Detalhes bibliográficos
Main Authors: Ojala, Pauli J., Paavilainen, Ville O., Vartiainen, Maria K., Tuma, Roman, Weeds, Alan G., Lappalainen, Pekka
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2002
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133594/
https://ncbi.nlm.nih.gov/pubmed/12429826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E02-03-0157
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