Contribution of Interleukin-12 (IL-12) and the CD28/B7 and CD40/CD40 Ligand Pathways to the Development of a Pathological T-Cell Response in IL-10-Deficient Mice

The ability of interleukin-10 (IL-10) to suppress accessory cell functions required for optimal T-cell activation makes it an important inhibitor of cell-mediated immunity. Thus, after infection with the protozoan parasite Toxoplasma gondii, IL-10 knockout (KO) mice develop a CD4(+)-T-cell-dependent...

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Main Authors: Wille, Ulrike, Villegas, Eric N., Craig, Linden, Peach, Robert, Hunter, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2002
Assuntos:
Fungal and Parasitic Infections
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC133089/
https://ncbi.nlm.nih.gov/pubmed/12438373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.12.6940-6947.2002
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