Contribution of Interleukin-12 (IL-12) and the CD28/B7 and CD40/CD40 Ligand Pathways to the Development of a Pathological T-Cell Response in IL-10-Deficient Mice

The ability of interleukin-10 (IL-10) to suppress accessory cell functions required for optimal T-cell activation makes it an important inhibitor of cell-mediated immunity. Thus, after infection with the protozoan parasite Toxoplasma gondii, IL-10 knockout (KO) mice develop a CD4(+)-T-cell-dependent...

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Pubblicato in:	Infect Immun
Autori principali:	Wille, Ulrike, Villegas, Eric N., Craig, Linden, Peach, Robert, Hunter, Christopher A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Fungal and Parasitic Infections
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133089/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12438373/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.70.12.6940-6947.2002
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