Transgenic Mice Expressing Human Interleukin-10 in the Antigen-Presenting Cell Compartment Show Increased Susceptibility to Infection with Mycobacterium avium Associated with Decreased Macrophage Effector Function and Apoptosis

Interleukin-10 (IL-10) is thought to play an important role in the regulation of microbial immunity. While T-cell-derived IL-10 has been shown to suppress cell-mediated immunity, there has been debate as to whether antigen presenting cell (APC)-derived cytokine can perform the same function in vivo....

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Bibliographic Details
Main Authors: Feng, Carl G., Kullberg, Marika C., Jankovic, Dragana, Cheever, Allen W., Caspar, Patricia, Coffman, Robert L., Sher, Alan
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Host Response and Inflammation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC133060/
https://ncbi.nlm.nih.gov/pubmed/12438341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.12.6672-6679.2002
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