The Furin Inhibitor Hexa-d-Arginine Blocks the Activation of Pseudomonas aeruginosa Exotoxin A In Vivo

The Pseudomonas aeruginosa exotoxin A (PEA) protein requires furin-mediated cleavage for manifestation of toxicity. We show here that the small stable furin inhibitor hexa-d-arginine amide effectively blocks PEA-induced cell lysis and is itself noncytotoxic. Administration of hexa-d-arginine to PEA-...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Sarac, Miroslav S., Cameron, Angus, Lindberg, Iris
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2002
Gaiak:
Molecular Pathogenesis
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC133042/
https://ncbi.nlm.nih.gov/pubmed/12438396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.12.7136-7139.2002
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