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Processing of Pseudomonas aeruginosa Exotoxin A Is Dispensable for Cell Intoxication

Exotoxin A is a major virulence factor of Pseudomonas aeruginosa. This toxin binds to a specific receptor on animal cells, allowing endocytosis of the toxin. Once in endosomes, the exotoxin can be processed by furin to generate a C-terminal toxin fragment that lacks the receptor binding domain and i...

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Detalhes bibliográficos
Main Authors: Morlon-Guyot, Juliette, Méré, Jocelyn, Bonhoure, Anne, Beaumelle, Bruno
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708563/
https://ncbi.nlm.nih.gov/pubmed/19380469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01390-08
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