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Structural Basis for Imipenem Inhibition of Class C β-Lactamases
To determine how imipenem inhibits the class C β-lactamase AmpC, the X-ray crystal structure of the acyl-enzyme complex was determined to a resolution of 1.80 Å. In the complex, the lactam carbonyl oxygen of imipenem has flipped by approximately 180° compared to its expected position; the electrophi...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology
2002
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC132770/ https://ncbi.nlm.nih.gov/pubmed/12435704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.12.3978-3980.2002 |
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