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Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain.

The crystal structure of the phosphotyrosine-binding domain (PTB) of the X11 protein has been determined, in complex with unphosphorylated peptides corresponding to a region of beta-amyloid precursor protein (betaAPP) that is required for receptor internalization. The mode of binding to X11 of the u...

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Bibliografske podrobnosti
Main Authors: Zhang, Z, Lee, C H, Mandiyan, V, Borg, J P, Margolis, B, Schlessinger, J, Kuriyan, J
Format: Artigo
Jezik:Inglês
Izdano: 1997
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1326298/
https://ncbi.nlm.nih.gov/pubmed/9321393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.20.6141
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