The role of positively charged amino acids and electrostatic interactions in the complex of U1A protein and U1 hairpin II RNA

Previous kinetic investigations of the N-terminal RNA recognition motif (RRM) domain of spliceosomal protein U1A, interacting with its RNA target U1 hairpin II, provided experimental evidence for a ‘lure and lock’ model of binding in which electrostatic interactions first guide the RNA to the protei...

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Autores principales: Law, Michael J., Linde, Michael E., Chambers, Eric J., Oubridge, Chris, Katsamba, Phinikoula S., Nilsson, Lennart, Haworth, Ian S., Laird-Offringa, Ite A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2006
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1326249/
https://ncbi.nlm.nih.gov/pubmed/16407334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkj436
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