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Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation

Accumulating in vitro evidence suggests that the p38 mitogen-activated protein kinase (MAPK) pathway is involved in endochondral ossification. To investigate the role of this pathway in endochondral ossification, we generated transgenic mice with expression in chondrocytes of a constitutively active...

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Detalhes bibliográficos
Main Authors: Zhang, Ren, Murakami, Shunichi, Coustry, Françoise, Wang, Ying, de Crombrugghe, Benoit
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1326166/
https://ncbi.nlm.nih.gov/pubmed/16387856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507979103
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