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ERK1 and ERK2 regulate chondrocyte terminal differentiation during endochondral bone formation

Chondrocytes in the epiphyseal cartilage undergo terminal differentiation prior to their removal through apoptosis. To examine the role of ERK1 and ERK2 in chondrocyte terminal differentiation, we generated Osx-Cre; ERK1(−/−); ERK2(flox/flox) mice (cKO(osx)), in which ERK1 and ERK2 were deleted in h...

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Detalhes bibliográficos
Publicado no:J Bone Miner Res
Main Authors: Chen, Zhijun, Yue, Susan X., Zhou, Guang, Greenfield, Edward M., Murakami, Shunichi
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4487783/
https://ncbi.nlm.nih.gov/pubmed/25401279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2409
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