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Absolute rate theories of epigenetic stability

Spontaneous switching events in most characterized genetic switches are rare, resulting in extremely stable epigenetic properties. We show how simple arguments lead to theories of the rate of such events much like the absolute rate theory of chemical reactions corrected by a transmission factor. Bot...

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Autors principals: Walczak, Aleksandra M., Onuchic, José N., Wolynes, Peter G.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1323203/
https://ncbi.nlm.nih.gov/pubmed/16361441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509547102
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