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Crystal structure of human T cell leukemia virus protease, a novel target for anticancer drug design

The successful development of a number of HIV-1 protease (PR) inhibitors for the treatment of AIDS has validated the utilization of retroviral PRs as drug targets and necessitated their detailed structural study. Here we report the structure of a complex of human T cell leukemia virus type 1 (HTLV-1...

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Detalhes bibliográficos
Main Authors: Li, Mi, Laco, Gary S., Jaskolski, Mariusz, Rozycki, Jan, Alexandratos, Jerry, Wlodawer, Alexander, Gustchina, Alla
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1317974/
https://ncbi.nlm.nih.gov/pubmed/16352712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509335102
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