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Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells
Using fluorescence resonance energy transfer (FRET) microscopy, we investigate how heterotrimeric G proteins interact with G protein-coupled receptors (GPCRs). In the absence of receptor activation, the α2A adrenergic and muscarinic M4 receptors are present on the cell membrane as dimers. Furthermor...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1317907/ https://ncbi.nlm.nih.gov/pubmed/16352729 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504778102 |
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