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Focal Adhesion Kinase Is a Substrate and Downstream Effector of SHP-2 Complexed with Helicobacter pylori CagA

Infection with cagA-positive Helicobacter pylori (H. pylori) is associated with atrophic gastritis, peptic ulcer, and gastric adenocarcinoma. The cagA gene product CagA is translocated from H. pylori into gastric epithelial cells and undergoes tyrosine phosphorylation by Src family kinases (SFKs). T...

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Main Authors: Tsutsumi, Ryouhei, Takahashi, Atsushi, Azuma, Takeshi, Higashi, Hideaki, Hatakeyama, Masanori
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2006
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1317644/
https://ncbi.nlm.nih.gov/pubmed/16354697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.1.261-276.2006
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