Inhibition of SIRT1 Catalytic Activity Increases p53 Acetylation but Does Not Alter Cell Survival following DNA Damage

Human SIRT1 is an enzyme that deacetylates the p53 tumor suppressor protein and has been suggested to modulate p53-dependent functions including DNA damage-induced cell death. In this report, we used EX-527, a novel, potent, and specific small-molecule inhibitor of SIRT1 catalytic activity to examin...

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Detalhes bibliográficos
Main Authors: Solomon, Jonathan M., Pasupuleti, Rao, Xu, Lei, McDonagh, Thomas, Curtis, Rory, DiStefano, Peter S., Huber, L. Julie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1317617/
https://ncbi.nlm.nih.gov/pubmed/16354677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.1.28-38.2006
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