Regulatable Gutless Adenovirus Vectors Sustain Inducible Transgene Expression in the Brain in the Presence of an Immune Response against Adenoviruses

In view of recent serious adverse events and advances in gene therapy technologies, the use of regulatable expression systems is becoming recognized as indispensable adjuncts to successful clinical gene therapy. In the present work we optimized high-capacity adenoviral (HC-Ad) vectors encoding the n...

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Autors principals: Xiong, Weidong, Goverdhana, Shyam, Sciascia, Sandra A., Candolfi, Marianela, Zirger, Jeffrey M., Barcia, Carlos, Curtin, James F., King, Gwendalyn D., Jaita, Gabriela, Liu, Chunyan, Kroeger, Kurt, Agadjanian, Hasmik, Medina-Kauwe, Lali, Palmer, Donna, Ng, Philip, Lowenstein, Pedro R., Castro, Maria G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2006
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1317549/
https://ncbi.nlm.nih.gov/pubmed/16352528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.1.27-37.2006
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