Directed Evolution of Streptomyces clavuligerus Deacetoxycephalosporin C Synthase for Enhancement of Penicillin G Expansion

The deacetoxycephalosporin C synthase from Streptomyces clavuligerus was directly modified for enhancement of penicillin G expansion into phenylacetyl-7-aminodeacetoxycephalosporanic acid, an important intermediate in the industrial manufacture of cephalosporin antibiotics. Nine new mutants, mutants...

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Bibliographische Detailangaben
Hauptverfasser: Wei, Chia-Li, Yang, Yunn-Bor, Deng, Chan-Hui, Liu, Wen-Chi, Hsu, Jyh-Shing, Lin, Yu-Ching, Liaw, Shwu-Huey, Tsai, Ying-Chieh
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Enzymology and Protein Engineering
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1317366/
https://ncbi.nlm.nih.gov/pubmed/16332884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.71.12.8873-8880.2005
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