Relevant Double Mutations in Bioengineered Streptomyces clavuligerus Deacetoxycephalosporin C Synthase Result in Higher Binding Specificities Which Improve Penicillin Bioconversion

Streptomyces clavuligerus deacetoxycephalosporin C synthase (ScDAOCS) is an important industrial enzyme for the production of 7-aminodeacetoxycephalosporanic acid, which is a precursor for cephalosporin synthesis. Single mutations of six amino acid residues, V275, C281, N304, I305, R306, and R307, w...

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Bibliografiska uppgifter
Huvudupphovsmän: Goo, Kian Sim, Chua, Chun Song, Sim, Tiow-Suan
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2008
Ämnen:
Enzymology and Protein Engineering
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258576/
https://ncbi.nlm.nih.gov/pubmed/18083859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02230-07
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