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Alterations of DNA and Chromatin Structures at Telomeres and Genetic Instability in Mouse Cells Defective in DNA Polymerase α

Telomere length is controlled by a homeostatic mechanism that involves telomerase, telomere-associated proteins, and conventional replication machinery. Specifically, the coordinated actions of the lagging strand synthesis and telomerase have been argued. Although DNA polymerase α, an enzyme importa...

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Autori principali: Nakamura, Mirai, Nabetani, Akira, Mizuno, Takeshi, Hanaoka, Fumio, Ishikawa, Fuyuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1316980/
https://ncbi.nlm.nih.gov/pubmed/16314528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.24.11073-11088.2005
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