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Autophosphorylation of DNA-Dependent Protein Kinase Regulates DNA End Processing and May Also Alter Double-Strand Break Repair Pathway Choice

Two highly conserved double-strand break (DSB) repair pathways, homologous recombination (HR) and nonhomologous end joining (NHEJ), function in all eukaryotes. How a cell chooses which pathway to utilize is an area of active research and debate. During NHEJ, the DNA-dependent protein kinase (DNA-PK)...

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Detalhes bibliográficos
Main Authors: Cui, Xiaoping, Yu, Yaping, Gupta, Shikha, Cho, Young-Moon, Lees-Miller, Susan P., Meek, Katheryn
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1316975/
https://ncbi.nlm.nih.gov/pubmed/16314509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.24.10842-10852.2005
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