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PGC-1α Coactivates PDK4 Gene Expression via the Orphan Nuclear Receptor ERRα: a Mechanism for Transcriptional Control of Muscle Glucose Metabolism

The transcriptional coactivator PGC-1α is a key regulator of energy metabolism, yet little is known about its role in control of substrate selection. We found that physiological stimuli known to induce PGC-1α expression in skeletal muscle coordinately upregulate the expression of pyruvate dehydrogen...

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Autors principals: Wende, Adam R., Huss, Janice M., Schaeffer, Paul J., Giguère, Vincent, Kelly, Daniel P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1316952/
https://ncbi.nlm.nih.gov/pubmed/16314495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.24.10684-10694.2005
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