Developing a programmed restriction endonuclease for highly specific DNA cleavage

Specific cleavage of large DNA molecules at few sites, necessary for the analysis of genomic DNA or for targeting individual genes in complex genomes, requires endonucleases of extremely high specificity. Restriction endonucleases (REase) that recognize DNA sequences of 4–8 bp are not sufficiently s...

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Main Authors: Eisenschmidt, Kristin, Lanio, Thomas, Simoncsits, András, Jeltsch, Albert, Pingoud, Vera, Wende, Wolfgang, Pingoud, Alfred
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2005
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1316111/
https://ncbi.nlm.nih.gov/pubmed/16356926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki1009
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