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Developing a programmed restriction endonuclease for highly specific DNA cleavage

Specific cleavage of large DNA molecules at few sites, necessary for the analysis of genomic DNA or for targeting individual genes in complex genomes, requires endonucleases of extremely high specificity. Restriction endonucleases (REase) that recognize DNA sequences of 4–8 bp are not sufficiently s...

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Библиографические подробности
Главные авторы: Eisenschmidt, Kristin, Lanio, Thomas, Simoncsits, András, Jeltsch, Albert, Pingoud, Vera, Wende, Wolfgang, Pingoud, Alfred
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2005
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1316111/
https://ncbi.nlm.nih.gov/pubmed/16356926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki1009
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