Matrix-Induced Inhibition of Membrane Binding Contributes to Human Immunodeficiency Virus Type 1 Particle Assembly Defects in Murine Cells

Defective human immunodeficiency virus type 1 (HIV-1) assembly in murine cells is accompanied by poor plasma membrane binding and proteolytic processing of the HIV-1 Gag precursor. Here, we show that such defects are induced by the propensity of the HIV-1 MA globular head to inhibit membrane binding...

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Autors principals: Hatziioannou, Theodora, Martin-Serrano, Juan, Zang, Trinity, Bieniasz, Paul D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
Matèries:
Genome Replication and Regulation of Viral Gene Expression
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1316038/
https://ncbi.nlm.nih.gov/pubmed/16306631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.24.15586-15589.2005
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