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Prion pathogenesis in the absence of Toll-like receptor signalling

To reach the brain from peripheral sites, prions must colonize various cell types within the lymphoreticular compartment. However, no prion entry receptors are yet known. Toll-like receptors (TLRs) are pattern-recognition receptors that bind a multitude of pathogens and are therefore candidates as e...

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書誌詳細
主要な著者: Prinz, Marco, Heikenwalder, Mathias, Schwarz, Petra, Takeda, Kiyoshi, Akira, Shizuo, Aguzzi, Adriano
フォーマット: Artigo
言語:Inglês
出版事項: 2003
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1315829/
https://ncbi.nlm.nih.gov/pubmed/12612611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.embor731
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