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Stop-transfer efficiency of marginally hydrophobic segments depends on the length of the carboxy-terminal tail

Hydrophobic stop-transfer sequences generally serve to halt the translocation of polypeptide chains across the endoplasmic reticulum membrane and become integrated as transmembrane α-helices. Using engineered glycosylation sites as topology reporters, we show that the length of the nascent chain bet...

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Detalhes bibliográficos
Main Authors: Hessa, Tara, Monné, Magnus, von Heijne, Gunnar
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1315826/
https://ncbi.nlm.nih.gov/pubmed/12612608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.embor728
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