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Stop-transfer efficiency of marginally hydrophobic segments depends on the length of the carboxy-terminal tail
Hydrophobic stop-transfer sequences generally serve to halt the translocation of polypeptide chains across the endoplasmic reticulum membrane and become integrated as transmembrane α-helices. Using engineered glycosylation sites as topology reporters, we show that the length of the nascent chain bet...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2003
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1315826/ https://ncbi.nlm.nih.gov/pubmed/12612608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.embor728 |
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