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The multidomain proapoptotic molecules Bax and Bak are directly activated by heat

During apoptosis, engagement of the mitochondrial pathway involves a decisive event characterized by the release of mitochondrial intermembrane space proteins, such as cytochrome c. This permeabilization of the mitochondrial outer membrane depends on activation and oligomerization of multidomain Bcl...

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Autori principali: Pagliari, Lisa J., Kuwana, Tomomi, Bonzon, Christine, Newmeyer, Donald D., Tu, Shine, Beere, Helen M., Green, Douglas R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1312392/
https://ncbi.nlm.nih.gov/pubmed/16330765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506712102
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