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SOCS1 restricts dendritic cells’ ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling

DC-based tumor vaccine research has largely focused on enhancing DC maturation/costimulation and antigen presentation in order to break tolerance against self tumor-associated antigens. DC immunization can activate autoreactive T cells but rarely causes autoimmune pathologies, indicating that self t...

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書目詳細資料
Main Authors: Evel-Kabler, Kevin, Song, Xiao-Tong, Aldrich, Melissa, Huang, Xue F., Chen, Si-Yi
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1312019/
https://ncbi.nlm.nih.gov/pubmed/16357940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26169
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