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p53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosis

The identification of transcriptional targets of the tumor suppressor p53 is crucial in understanding mechanisms by which it affects cellular outcomes. Through expression array analysis, we identified cyclooxygenase 2 (Cox-2), whose expression was inducible by wild-type p53 and DNA damage. We also f...

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Detalhes bibliográficos
Main Authors: Han, Jeong A., Kim, Jong-Il, Ongusaha, Pat P., Hwang, Daniel H., Ballou, Leslie R., Mahale, Alka, Aaronson, Stuart A., Lee, Sam W.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2002
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC131088/
https://ncbi.nlm.nih.gov/pubmed/12411481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf591
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