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Reversible stages of the low-pH-triggered conformational change in influenza virus hemagglutinin

The refolding of the prototypic fusogenic protein hemagglutinin (HA) at the pH of fusion is considered to be a concerted and irreversible discharge of a loaded spring, with no distinct intermediates between the initial and final conformations. Here, we show that HA refolding involves reversible conf...

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Detalhes bibliográficos
Main Authors: Leikina, Eugenia, Ramos, Corinne, Markovic, Ingrid, Zimmerberg, Joshua, Chernomordik, Leonid V.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC131056/
https://ncbi.nlm.nih.gov/pubmed/12411488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf559
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