Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia

Sarcomere protein gene mutations cause hypertrophic cardiomyopathy (HCM), a disease with distinctive histopathology and increased susceptibility to cardiac arrhythmias and risk for sudden death. Myocyte disarray (disorganized cell–cell contact) and cardiac fibrosis, the prototypic but protean featur...

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Main Authors: Wolf, Cordula M., Moskowitz, Ivan P. G., Arno, Scott, Branco, Dorothy M., Semsarian, Christopher, Bernstein, Scott A., Peterson, Michael, Maida, Michael, Morley, Gregory E., Fishman, Glenn, Berul, Charles I., Seidman, Christine E., Seidman, J. G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2005
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1307513/
https://ncbi.nlm.nih.gov/pubmed/16332958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509145102
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