Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia

Sarcomere protein gene mutations cause hypertrophic cardiomyopathy (HCM), a disease with distinctive histopathology and increased susceptibility to cardiac arrhythmias and risk for sudden death. Myocyte disarray (disorganized cell–cell contact) and cardiac fibrosis, the prototypic but protean featur...

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Autori principali: Wolf, Cordula M., Moskowitz, Ivan P. G., Arno, Scott, Branco, Dorothy M., Semsarian, Christopher, Bernstein, Scott A., Peterson, Michael, Maida, Michael, Morley, Gregory E., Fishman, Glenn, Berul, Charles I., Seidman, Christine E., Seidman, J. G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2005
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1307513/
https://ncbi.nlm.nih.gov/pubmed/16332958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509145102
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