Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia

Sarcomere protein gene mutations cause hypertrophic cardiomyopathy (HCM), a disease with distinctive histopathology and increased susceptibility to cardiac arrhythmias and risk for sudden death. Myocyte disarray (disorganized cell–cell contact) and cardiac fibrosis, the prototypic but protean featur...

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Detalhes bibliográficos
Main Authors: Wolf, Cordula M., Moskowitz, Ivan P. G., Arno, Scott, Branco, Dorothy M., Semsarian, Christopher, Bernstein, Scott A., Peterson, Michael, Maida, Michael, Morley, Gregory E., Fishman, Glenn, Berul, Charles I., Seidman, Christine E., Seidman, J. G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1307513/
https://ncbi.nlm.nih.gov/pubmed/16332958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509145102
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