Synergistic Effect of Nod1 and Nod2 Agonists with Toll-Like Receptor Agonists on Human Dendritic Cells To Generate Interleukin-12 and T Helper Type 1 Cells

A synthetic Nod2 agonist, muramyldipeptide (MDP), and two Nod1 agonists, FK565 and FK156, mimic the bacterial peptidoglycan moiety and are powerful adjuvants that induce cell-mediated immunity, especially delayed-type hypersensitivity. In this study, we used human dendritic cell (DC) cultures to exa...

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Hlavní autoři: Tada, Hiroyuki, Aiba, Setsuya, Shibata, Ken-Ichiro, Ohteki, Toshiaki, Takada, Haruhiko
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2005
Témata:
Host Response and Inflammation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1307098/
https://ncbi.nlm.nih.gov/pubmed/16299289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.12.7967-7976.2005
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