Community-Based Safety, Immunogenicity, and Transmissibility Study of the Shigella sonnei WRSS1 Vaccine in Israeli Volunteers

We describe the first community-based evaluation of Shigella sonnei strain WRSS1, a live, oral candidate vaccine attenuated by a 212-bp deletion in the virG (or icsA) plasmid virulence gene. Three single-dose regimens of WRSS1 (5 × 10(3) CFU, 2 × 10(4) CFU, and 4 × 10(5) CFU) were tested with cohort...

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Autori principali: Orr, Nadav, Katz, David E., Atsmon, Jacob, Radu, Paull, Yavzori, Miri, Halperin, Tamar, Sela, Tamar, Kayouf, Raid, Klein, Zivit, Ambar, Ruhama, Cohen, Dani, Wolf, Marcia K., Venkatesan, Malabi M., Hale, Thomas L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
Soggetti:
Microbial Immunity and Vaccines
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1307051/
https://ncbi.nlm.nih.gov/pubmed/16299296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.12.8027-8032.2005
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