Familial hemiplegic migraine mutations increase Ca(2+) influx through single human Ca(V)2.1 channels and decrease maximal Ca(V)2.1 current density in neurons

Insights into the pathogenesis of migraine with aura may be gained from a study of human Ca(V)2.1 channels containing mutations linked to familial hemiplegic migraine (FHM). Here, we extend the previous single-channel analysis to human Ca(V)2.1 channels containing mutation V1457L. This mutation incr...

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Detalhes bibliográficos
Main Authors: Tottene, Angelita, Fellin, Tommaso, Pagnutti, Stefano, Luvisetto, Siro, Striessnig, Joerg, Fletcher, Colin, Pietrobon, Daniela
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC130625/
https://ncbi.nlm.nih.gov/pubmed/12235360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.192242399
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