Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) inhibit peroxynitrite formation, NF-κB and AP-1 activation, and IL-8 gene expression in human leukocytes

Lipoxin A(4) (LXA(4)) and aspirin-triggered 15-epi-LXA(4) (ATL) are emerging as endogenous braking signals for neutrophil-mediated tissue injury. Recent studies indicate that peroxynitrite (ONOO(−)) may function as an intracellular signal for the production of IL-8, a potent proinflammatory cytokine...

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Hlavní autoři: József, Levente, Zouki, Christine, Petasis, Nicos A., Serhan, Charles N., Filep, János G.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2002
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC130622/
https://ncbi.nlm.nih.gov/pubmed/12235371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.202296999
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