Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation: Reversibility by drugs that enhance cAMP signaling

Changes in hippocampal function seem critical for cognitive impairment in Alzheimer's disease (AD). Although there is eventual loss of synapses in both AD and animal models of AD, deficits in spatial memory and inhibition of long-term potentiation (LTP) precede morphological alterations in the...

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Detalhes bibliográficos
Main Authors: Vitolo, Ottavio V., Sant'Angelo, Antonino, Costanzo, Vincenzo, Battaglia, Fortunato, Arancio, Ottavio, Shelanski, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC130613/
https://ncbi.nlm.nih.gov/pubmed/12244210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.172504199
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