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Pyrimethamine and WR99210 exert opposing selection on dihydrofolate reductase from Plasmodium vivax

Plasmodium vivax is a major public health problem in Asia and South and Central America where it is most prevalent. Until very recently, the parasite has been effectively treated with chloroquine, but resistance to this drug has now been reported in several areas. Affordable alternative treatments f...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Principais autores: Hastings, Michele D., Sibley, Carol Hopkins
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2002
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC130599/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12198181/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.182295999
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