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Dominant-negative inhibition of prion replication in transgenic mice

Our discovery of dominant-negative inhibition of prion formation in cultured cells provided an explanation for the resistance of some sheep to scrapie and humans to Creutzfeldt–Jakob disease. To determine whether dominant-negative inhibition occurs in vivo, we produced transgenic (Tg) mice expressin...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Perrier, Véronique, Kaneko, Kiyotoshi, Safar, Jiri, Vergara, Julie, Tremblay, Patrick, DeArmond, Stephen J., Cohen, Fred E., Prusiner, Stanley B., Wallace, Andrew C.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC130589/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12271119/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.182425299
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