Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation

The development of helper T (Th) cell subsets, which secrete distinct cytokines, plays an important role in determining the type of immune response. The IL-4-mediated Janus kinase–signal transducer and activator of transcription signaling pathway is crucial for mediating Th2 cell development. Notabl...

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Bibliographic Details
Main Authors: Seki, Yoh-ichi, Hayashi, Katsuhiko, Matsumoto, Akira, Seki, Noriyasu, Tsukada, Jun, Ransom, John, Naka, Tetsuji, Kishimoto, Tadamitsu, Yoshimura, Akihiko, Kubo, Masato
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC130576/
https://ncbi.nlm.nih.gov/pubmed/12242343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.202477099
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