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Induced Fit and the Entropy of Structural Adaptation in the Complexation of CAP and λ-Repressor with Cognate DNA Sequences
Molecular dynamics (MD) simulations of 5 ns on protein-DNA complexes of catabolite-activator protein (CAP), λ-repressor, and their corresponding uncomplexed protein and DNA, are reported. These cases represent two extremes of DNA bending, with CAP DNA bent severely and the λ-operator nearly straight...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Biophysical Society
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1305465/ https://ncbi.nlm.nih.gov/pubmed/15731390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.053843 |
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