Induced Fit and the Entropy of Structural Adaptation in the Complexation of CAP and λ-Repressor with Cognate DNA Sequences

Molecular dynamics (MD) simulations of 5 ns on protein-DNA complexes of catabolite-activator protein (CAP), λ-repressor, and their corresponding uncomplexed protein and DNA, are reported. These cases represent two extremes of DNA bending, with CAP DNA bent severely and the λ-operator nearly straight...

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Hlavní autoři: Dixit, Surjit B., Andrews, David Q., Beveridge, D. L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Biophysical Society 2005
Témata:
Biophysical Theory and Modeling
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1305465/
https://ncbi.nlm.nih.gov/pubmed/15731390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.053843
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